基于EBT3胶片开展电子FLASH放疗剂量测量研究

王诗岚; 羊奕伟; 程德琪; 唐镭迅; 吴岱

doi:10.11884/HPLPB202436.240095

基于EBT3胶片开展电子FLASH放疗剂量测量研究

doi: 10.11884/HPLPB202436.240095

王诗岚^1,,
羊奕伟^1, ,,
程德琪²,
唐镭迅³,
吴岱^1, ,

1.
中国工程物理研究院应用电子学研究所，四川绵阳 621900
2.
哈尔滨工程大学核科学与技术学院，哈尔滨 150001
3.
南华大学核科学技术学院，湖南衡阳 421001

基金项目: 国家自然科学基金项目(12375318)

详细信息

作者简介:
王诗岚，wangshilan2024@163.com

通讯作者:
羊奕伟，winfield1920@126.com

吴　岱，wudai04@163.com。

中图分类号: R144.1
计量
- 文章访问数: 302
- HTML全文浏览量: 151
- PDF下载量: 35
- 被引次数: 0
出版历程
- 收稿日期: 2024-03-14
- 修回日期: 2024-09-14
- 录用日期: 2024-09-02
- 网络出版日期: 2024-09-23
- 刊出日期: 2024-11-08

Study of electron FLASH radiotherapy dose measurement based on EBT3 film

Wang Shilan^1
,,
Yang Yiwei^{1
, ,},
Cheng Deqi²,
Tang Leixun³,
Wu Dai^{1
, ,}

1.
Institute of Applied Electronics, CAEP, Mianyang 621900, China
2.
College of Nuclear Science and Technology, Harbin Engineering University, Harbin 150001, China
3.
School of Nuclear Science and Technology, University of South China, Hengyang 421001, China

摘要

摘要: 闪光放疗使用超高剂量率在毫秒时间内将剂量全部注入靶区，其超高剂量率使现有的在线剂量计基本失效，目前通常使用辐射显色胶片来测量剂量。基于中国工程物理研究院应用电子学研究所研制的电子加速器搭建了电子FLASH放疗平台，基于EBT3胶片的快速读出方法，研究了此平台的剂量率范围及剂量分布。实验结果表明，EBT3胶片的快速读出方法可用于电子FLASH放疗的剂量测量，在源皮距100 cm及深度1 cm处剂量率在240～290 Gy/s之间；电子束到达模体表面的平均能量的波动会导致靶区约±5%的剂量波动；面剂量分布满足平坦性在±5%以内和对称性在±3%以内的要求。
- 放射治疗 /
- 超高剂量率 /
- EBT3胶片 /
- 剂量测量 /
- 电子FLASH放疗平台
Abstract: FLASH radiotherapy delivers the entire dose to the target area within milliseconds using ultra-high dose rates, rendering existing online dosimeters essentially ineffective. Currently, radiation-sensitive films are commonly employed for dose measurement. Utilizing an electron accelerator developed by the Institute of Applied Electronics of CAEP, an electron FLASH radiotherapy platform was established to investigate the dose rate range and dose distribution using the EBT3 film’s rapid readout method. Experimental results indicate that the rapid readout method of EBT3 films is applicable for dose measurement in electron FLASH radiotherapy, with dose rates ranging from 240 Gy/s to 290 Gy/s at a source-to-skin distance of 100 cm and a depth of 1 cm. Fluctuations in the average energy of the electron beam reaching the surface of the phantom result in dose fluctuations of approximately ±5% in the target area. The surface dose distribution meets the requirements of flatness within ±5% and symmetry within ±3%.
- radiation therapy /
- ultra-high dose rate /
- Gafchromic EBT3 /
- dosimetry /
- electron FLASH radiotherapy platform

HTML全文

图 1 电子FLASH辐照平台示意图(俯视图)

Figure 1. Schematic diagram of electron FLASH radiotherapy platform (top view)

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图 2 胶片标定结果

Figure 2. Film calibration result

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图 3 不同标定曲线之间测量剂量的相对偏差

Figure 3. Relative deviation in measured dose between different calibration curves

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图 4 不同剂量曲线的剂量分布测量结果

Figure 4. Measurement results of dose distribution for different dose curves

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图 5 电子束剂量分布特征

Figure 5. Electron beam dose distribution characteristics

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