Abstract: The mid-infrared supercontinuum generation in telluride photonic crystal fiber with 2 m wavelength region pulsed laser pumping is numerically investigated. The material Raman response function is indirectly obtained from the Raman gain spectrum. The effective refractive index of the fundamental mode in telluride photonic crystal fiber is obtained using the material refractive index and waveguide structure through COMSOL software. Then the calculated dispersion and confinement loss of telluride photonic crystal fiber are plotted using the effective refractive index of the fundamental mode. The supercontinuum generation process in telluride photonic crystal fiber is studied by the adaptive split-step Fourier method. Assuming a 50 fs pulsed laser launched into telluride photonic crystal fiber with 1.96 m central wavelength and 20 kW peak power, a mid-infrared supercontinuum with a bandwidth from 1 m to 4.5 m is obtained when the fiber length is 6 cm.