Abstract: Based on the discussion of the law of the interaction between optic field and fluid field, we adopted the physical model for high energy laser beams crossing through three-dimensional high speed flow. A two-dimensional Hartmann wavefront sensor was used to measure the aero-optic effects when the high energy laser beam passed through a high speed airflow in the wind tunnel. The density and temperature maps of fluid field and far-field optical path difference map of laser beams were obtained. The disturbance of the fluid field caused by radiation heating and the changing of laser beam optics aberrations after the beam passing through the fluid field were discussed. The results show that the interaction between lasers and the high speed airflow has little influence on the temperature and density of the airflow when the air is not ionized.