Abstract: The effects of microwave irradiation on the certain integrate circuit radio fuse from aspects of service and normal working state are studied. The damaged and accidental explosion threshold values for microwave irradiation on the radio fuse under test are determined, which are 140~150 kW/cm2 and 100 kW/cm2 respectively. The effecting mechanism of microwave irradiation is analyzed, which shows that the high-frequency module and low-frequency module of radio fuse can be destroyed by antenna coupling for microwave irradiation. Experiments show that microwave irradiation can lead to false action of electronic modules and result in malfunction of explosion executing-device, that is the ultimate reason of accidental explosion for radio fuse under test.