Abstract: A experimental method, Pressure Loading by Steps, is designed to measure the fracture and buckling failure pressures of hollow glass microspheres(HGM) for use in laser fusion experiments. The failure pressures of 3 kinds of HGM with out-diameters of 350m m～550m m and wall-thickness less than 1.1m m and their glass’s elastic moduli and tensile strengthes are measured experimentally. From the results, experimental formulae are obtained to evaluate the failure pressures of HGM in different out-diameter and wall-thickness without any test. Moreover, the experimental error sources and ways to improve them are discussed.