Abstract: For purpose of calculating the bare wire and shielded wire responses in Ｘ-ray environment, Holland thin wire model and (transmission line) TL model were used respectively. The effect of wire load, radius, X-ray energy and medium layer thickness on the responses were discussed based on the results of test. The numerical results indicate that the responses are not sensitive to the change of small load, but it is just the opposite for large load. The width of current pulse and the load energy increases with the increase of load, while the amplitude of the current decreases, and the load power has a peak value. The responses are in proportion to the inner conductor radius, and in inverse proportion to the X-ray energy. For different medium layer thickness, there exists peak value to the curre