Abstract: In order to study the laser interference effects of multi-spectral cameras, interference saturation experiments were conducted on a three-channel CCD camera using red, green, and blue lasers. The saturation threshold at different wavelengths was measured for each channel. The difference among saturation thresholds of different channels was analyzed from the operating principle of the camera, and the saturation interference of single-wavelength and multi-wavelength coupling was comparatively studied under the same power. It is found that the coupled multi-wavelength laser has better interference effect than the single-wavelength one.