Abstract: This paper mainly analyzed the characteristics of nuclear physics experiments and their requirements for analog-digital converter (ADC). Based on technical index comparison of three ADC chips, ADS8472 was selected as the acquisition chip, which has 16 bit resolution and successive approximation register (SAR) framework, with differential and integral nonlinearities of ±0.50 and ±0.65 least significant bit, respectively. According to the actual circuit applications, the architecture of the pulse amplitude acquisition and analysis system was introduced, and its working principle was described. With linear power supply chip, fluctuations of the fan-out voltages were all less than 1 mV after a long-period (72 h) full-load test.