Abstract: Tritium self-sufficiency of Z-pinch driven fusion-fission hybrid reactor (Z-FFR) is the basis of its long-term operation. In order to analyse the conditions of tritium self-sufficiency, a modified tritium fuel cycle model and equations of Z-FFR based on mean residence time calculation method were established. Through theoretical analysis and calculation, the tritium mass-flow of Z-pinch exhaust processing system(ZEP), tritium extraction system(TES), isotope separation system(ISS), water detriation system(WDS) were got. The results of tritium mass-flow are 52.30, 25.40, 81.30, 3.60 g/day, and tritium inventory are 52.30, 25.40, 8.13, 1.80 g. Meanwhile, criteria of tritium self-sufficiency were given out based on mass-flow. The design parameters can meet this requirements. Then the complementary relationship of burning rate, tritium breeding ratio and extraction efficiency under tritium self-sufficiency critical condition were analyzed.