Feasibility analysis for radionuclide therapy dose measurement based on Cerenkov radiation
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摘要: 针对现有核素治疗中内照射剂量测量缺乏简单、高效方法的问题，基于内照射剂量与切伦科夫辐射之间的关系，提出一种基于切伦科夫辐射的核素治疗内照射剂量测量的新方法。利用蒙特卡罗计算程序Geant4，模拟放射性核素131I在水体模型和甲状腺模型中产生切伦科夫辐射与剂量沉积的分布情况，并定量分析切伦科夫光子数与剂量之间的关系。计算结果表明：在水体模的半径方向上切伦科夫光子数与剂量之间有着相同的变化趋势，且两者有着相同的二维分布规律；核素131I在介质中产生的切伦科夫光子数与剂量两者之间存在一定的线性关系，且这种线性关系与核素的分布情况无关。研究结果证实，将这种放射性核素在介质中产生的切伦科夫辐射应用于内照射剂量学具有非常大的研究潜力和价值。Abstract: This paper aims to determine the relationship between the emission of Cerenkov photon number and radiation dose from internal radionuclide and proposes, a potential dosimetry based on Cerenkov radiation for radionuclide therapy. Water and thyroid phantoms were used to simulate the distribution of Cerenkov photon number and dose deposition produced by radionuclide 131I through Geant4 toolkit, and the relationship between Cerenkov photon number and dose deposition was quantitatively analyzed. The calculation results show that the Cerenkov photon number and dose deposition have the same distribution trend in water phantom, and this relative distribution relationship also exists in thyroid phantom. Moreover, the Cerenkov photon number exhibits a specific quantitative relation to dose deposition.
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Key words:
- Cerenkov radiation /
- internal dose /
- radionuclide /
- radionuclide therapy /
- Monte Carlo method
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