Design of a ±5 kV bipolar linear transformer driver and its application in cell electroporation
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摘要: 提出了一种双极性直线型变压器驱动源布局结构，实现了双极性直线型变压器驱动源模块的灵活叠加。通过调节驱动电路的驱动电压来调控金属氧化物半导体场效应晶体管的导通时间，精确控制脉冲电压的上升时间。在直线型变压器驱动源结构中引入了磁芯-铜柱一体结构和反向过冲泄放回路，优化了电磁兼容性，减小了脉冲波尾的反向过冲。研制的双极性直线型变压器驱动源在1 kHz的频率下能够稳定输出脉冲宽度为1 μs、幅值为±5 kV的脉冲电压，上升时间从30 ns到100 ns内连续可调。利用研制的双极性直线型变压器驱动源开展了细胞不可逆电穿孔实验。Abstract: This paper proposes a layout structure of the pulsed power generator based on the bipolar linear transformer driver, achieving flexible stacking of the bipolar linear transformer driver modules. The conduction time of the metal-oxide-semiconductor field effect transistor is regulated by adjusting the voltage of the driver circuit, enabling precise control over the rise time of the pulsed voltage. An integrated core-copper pillar structure and a reverse overshoot discharge circuit are introduced in the linear transformer driver structure, which optimizes the electromagnetic compatibility and reduces the reverse overshoot at the tail of the pulsed waveform. The developed bipolar linear transformer driver device can stably output ±5 kV pulsed voltage with 1 kHz frequency and 1 μs pulse width. The rise time of the pulsed voltage is continuously adjustable from 30 ns to 100 ns. The irreversible electroporation experiments on cells are carried out using the bipolar linear transformer driver.
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Key words:
- linear transformer driver /
- bipolar /
- nanosecond pulse /
- irreversible electroporation
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图 4 磁芯-铜柱一体结构
Figure 4. Core-copper pillar monolithic structure
(a) partial connection simulation results (b) full connection simulation results (c) schematic diagram; (d) real product picture
图 5 主电路和泄放电路的示意图
Figure 5. Schematic diagram of the main circuit and discharge circuit
图 7 不同驱动电压下的正极性脉冲电压波形
Figure 7. Positive polarity output waveforms under different drive voltages
图 8 有无泄放回路的正极性输出波形图
Figure 8. Positive polarity output waveforms with and without a discharge circuit
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