Calculation of cellular S values for α particle based on Monte Carlo simulation
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摘要: 在放射性免疫治疗以及硼中子俘获治疗（BNCT）等放射性治疗过程中，粒子通过与人体组织材料相互作用产生次级电子将能量传递给人体组织，放射性核素在细胞尺度分布的不均匀性将严重影响靶区剂量分布。为深入了解放射性核素在细胞中不同位置分布对靶区剂量影响，采用基于历史凝聚算法的Monte Carlo 工具包Geant4编写了细胞S值计算程序。计算了2种细胞尺寸，12种粒子能量，3种源分布方式的细胞S值，与医学内照射剂量（MIRD）委员会解析算法的计算结果进行对比，发现两者差异在1%以内。证明了Geant4在m尺度下细胞剂量计算的可行性，并对BNCT治疗过程中产生的粒子(1.47 MeV与1.78 MeV)的细胞S值进行计算。Abstract: In the case of radiation therapy and BNCT, alpha particles transport the energy to human tissue by second electrons. However, in cellular scale alpha sources do not have a uniform distribution. In order to get the target dosimetry discrepancy by different source locations, a computational application to calculate the S value with Monte Carlo toolkit Geant4 was programmed. S values of two dimensions, twelve energies, and three source locations were calculated. Compared with MIRD results, the difference between both is within 1%. Geant4 toolkit to calculate the cell dosimetry was proved to be believable and flexible. A couple of S values of alpha particles produced in BNCT with 1.47 MeV and 1.78 MeV were calculated. To some extent these values can become reference values in clinical therapy.
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Key words:
- microdosimetry /
- Monte Carlo method /
- alpha particle /
- S value /
- BNCT /
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