Novel magnetic-modulated proton therapy method and corresponding modulation mechanism

Shao Wencheng; Tang Xiaobin; Geng Changran; Shu Diyun; Gong Chunhui; Ai Yao; Zhang Xudong; Yu Haiyan

doi:10.11884/HPLPB201729.170220

Volume 29 Issue 12

Feb. 2018

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Article Navigation > High Power Laser and Particle Beams > 2017 > 29(12): 126015

Wang Xuede, Li Yiming, Nie Xiangfan, et al. Effects of micro-scale laser shock peening on surface integrity of DZ17G alloy[J]. High Power Laser and Particle Beams, 2017, 29: 089001. doi: 10.11884/HPLPB201729.160550

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Shao Wencheng, Tang Xiaobin, Geng Changran, et al. Novel magnetic-modulated proton therapy method and corresponding modulation mechanism[J]. High Power Laser and Particle Beams, 2017, 29: 126015. doi: 10.11884/HPLPB201729.170220

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Novel magnetic-modulated proton therapy method and corresponding modulation mechanism

doi: 10.11884/HPLPB201729.170220

1.
Department of Nuclear Science and Engineering,Nanjing University of Aeronautics and Astronautics,Nanjing 210016,China;
2.
Harbin Medical University Cancer Hospital,Harbin 150081,China

Received Date: 2017-06-20
Rev Recd Date: 2017-07-27
Publish Date: 2017-12-15

Abstract

Abstract

This study proposes a novel magnetic-modulated proton therapy, explores tumor and organ doses as functions of the magnetic modulation method, and investigates the application of the magnetic-modulated therapy in curing organ-surrounded tumors. Based on Geant4 Monte Carlo code, we constructed an ideal organ-surrounded structure and an abdominal structure comprising a pancreatic tumor. Bragg peak positions of proton beams were modulated through altering the strengths and directions of the magnetic fields inside the two geometric structures. Following the magnetic-deflected transportation tracks, the proton beams were modulated to bypass the vital organs and irradiate the tumor. For the ideal organ-surrounding configuration, the tumor can be sufficiently covered by 95% relative doses, and the vital organ volume receiving proton irradiations can be controlled to nearly zero. For the abdominal structure comprising the pancreatic tumor, the proton beams modulated by magnetic fields can bypass the spinal cord and left kidney and irradiate the pancreatic tumor. Sufficient coverage of 95% relative doses can be achieved through the magnetic-modulated proton therapy method.
- Monte Carlo method,
- particle transport,
- Geant4,
- proton therapy,
- magnetic modulation,
- Bragg peak,
- organ protection

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