Feasibility analysis for radionuclide therapy dose measurement based on Cerenkov radiation

This paper aims to determine the relationship between the emission of Cerenkov photon number and radiation dose from internal radionuclide and proposes, a potential dosimetry based on Cerenkov radiation for radionuclide therapy. Water and thyroid phantoms were used to simulate the distribution of Cerenkov photon number and dose deposition produced by radionuclide 131I through Geant4 toolkit, and the relationship between Cerenkov photon number and dose deposition was quantitatively analyzed. The calculation results show that the Cerenkov photon number and dose deposition have the same distribution trend in water phantom, and this relative distribution relationship also exists in thyroid phantom. Moreover, the Cerenkov photon number exhibits a specific quantitative relation to dose deposition.