Skin damage in mice induced by different power densities of 1064 nm laser

Liu Zhibo; Ma Qiong; Zhou Xun; Wei Yu; Kang Hongxiang

doi:10.11884/HPLPB202335.220292

Volume 35 Issue 3

Mar. 2023

Turn off MathJax

Article Contents

Article Navigation > High Power Laser and Particle Beams > 2023 > 35(3): 031001

Liu Zhibo, Ma Qiong, Zhou Xun, et al. Skin damage in mice induced by different power densities of 1064 nm laser[J]. High Power Laser and Particle Beams, 2023, 35: 031001. doi: 10.11884/HPLPB202335.220292

Citation:

Liu Zhibo, Ma Qiong, Zhou Xun, et al. Skin damage in mice induced by different power densities of 1064 nm laser[J]. High Power Laser and Particle Beams, 2023, 35: 031001. doi: 10.11884/HPLPB202335.220292

Citation:

PDF( 17320 KB)

Skin damage in mice induced by different power densities of 1064 nm laser

doi: 10.11884/HPLPB202335.220292

Institute of Radiation Medicine, Academy of Military Medical Science, Academy of Military Science PLA China, Beijing 108502, China

Received Date: 2022-09-17
Accepted Date: 2023-01-11
Rev Recd Date: 2023-01-11

Available Online: 2023-02-07

Publish Date: 2023-03-01

Abstract

Abstract

The thermal damage of mouse skin under different output power of 1064 nm laser was studied by experiment and theoretical analysis. The degree of thermal injury of mouse skin tissue was evaluated by dermoscope and optical coherence tomography (OCT), and the theoretical analysis was made according to Arrhenius thermal damage equation, and the results were compared with the experimental results. The results show that when the laser’s continuous irradiation time is 400 ms and the laser output power density is less than 958 W/cm², there is no obvious damage; when the laser output power density is 958−1160 W/cm², the damage is white blister-like; when the laser output power density is 1160−1370 W/cm², the damage is a shallow pit-like macula with a circle of bulging white skin blisters around the damage spot; when the laser power density is at 1370−2190 W/cm², the damage is a red pit-like spot, and there is black-yellow eschar around the injury spot.
- 1064 nm laser,
- cutaneous thermal injury,
- Arrhenius heat damage equation,
- thermal injury model,
- thermal injury grading

FullText(HTML)

References(15)

References

[1]	激光军事应用[J]. 中国光学与应用光学文摘, 2001, 15(5): 31-33 Laser military application[J]. Chinese Optics, 2001, 15(5): 31-33
[2]	张延令. 激光在外科中的应用[J]. 国外医学. 外科学分册, 1984(3):143-146 Zhang Yanling. Application of laser in surgery[J]. Foreign Medical Sciences. Surgery Section, 1984(3): 143-146
[3]	宋秋伦, 洪伟, 王倩. 逍遥丸联合调Q Nd: YAG 1064 nm激光治疗黄褐斑疗效分析[J]. 中国美容医学, 2022, 31(4):114-116 Song Qiulun, Hong Wei, Wang Qian. Effect of Xiaoyao pill combined with Nd: YAG 1 064 nm laser on chloasma[J]. Chinese Journal of Aesthetic Medicine, 2022, 31(4): 114-116
[4]	左娜, 陶凯. 1064 nm Nd: YAG激光联合水光注射治疗面部皮肤老化疗效观察[J]. 中国美容医学, 2022, 31(5):23-25 Zuo Na, Tao Kai. Efficacy of 1064 nm Nd: YAG laser combined with hyaluronic acid injection in the treatment of facial rejuvenation[J]. Chinese Journal of Aesthetic Medicine, 2022, 31(5): 23-25
[5]	施添霖. 积雪苷联合长脉宽1064 nm激光治疗瘢痕疙瘩的疗效观察[D]. 杭州: 浙江中医药大学, 2019 Shi Tianlin. The therapeutic effect of asiaticoside ointment combined with long pulse 1064 nm laser on keloid[D]. Hangzhou: Zhejiang Chinese Medical University, 2019
[6]	冯微, 冯啸, 陈燕, 等. 长脉宽1064 nm激光在整形美容应用中的进展[J]. 中国美容整形外科杂志, 2021, 32(11):696-698 doi: 10.3969/j.issn.1673-7040.2021.11.016 Feng Wei, Feng Xiao, Chen Yan, et al. Development of a 1064 nm long pulse width laser for cosmetic and cosmetic applications[J]. Chinese Journal of Aesthetic and Plastic Surgery, 2021, 32(11): 696-698 doi: 10.3969/j.issn.1673-7040.2021.11.016
[7]	李忠明, 骆清明. 激光对生物组织热和热致机械损伤的物理分析[J]. 激光生物学报, 2000, 9(2):81-84 Li Zhongming, Luo Qingming. Physical analysis on tissues’ heat and heatinduced injury for laser irradiation[J]. Acta Laser Biology Sinica, 2000, 9(2): 81-84
[8]	王振华, 单健, 陈铀, 等. 激光对生物组织的热损伤机理研究及临床应用探讨[J]. 激光杂志, 2003, 24(1):60-62 Wang Zhenhua, Shan Jian, Chen You, et al. A study on thermal damage of laser tissue and clinical application[J]. Laser Journal, 2003, 24(1): 60-62
[9]	吕晨阳, 战仁军. 激光-生物组织光热效应模型综述[J]. 激光杂志, 2021, 42(1):17-24 Lv Chenyang, Zhan Renjun. Model review of laser-biological tissue photo-thermal effect[J]. Laser Journal, 2021, 42(1): 17-24
[10]	陈安宁, 吴家辉, 李希靖. 激光对生物组织热损伤的计算机模拟[J]. 光电子·激光, 2001, 12(2):212-214 Chen Anning, Wu Jiahui, Li Xijing. Computer simulation of thermal damage to biological tissue during laser irradiation[J]. Journal of Optoelectronics·Laser, 2001, 12(2): 212-214
[11]	朱光明, 朱丹, 骆清铭, 等. 激光热疗中生物组织的光热特性响应以及动态热损伤研究[J]. 中国生物医学工程学报, 2004, 23(2):157-162 Zhu Guangming, Zhu Dan, Luo Qingming, et al. Study on the optical-thermal response and dynamic thermal damage of bio-tissue during laser thermotherapy[J]. Chinese Journal of Biomedical Engineering, 2004, 23(2): 157-162
[12]	吴秀山, 侯宇, 李希靖. 强激光作用下生物组织热损伤问题的研究[J]. 中国计量学院学报, 2002, 13(2):135-138 Wu Xiushan, Hou Yu, Li Xijing. The research on thermal damage in biological tissues induced by high-irradiance-laser[J]. Journal of China Jiliang University, 2002, 13(2): 135-138
[13]	周巡, 马琼, 刘智搏, 等. 1064 nm激光不同辐照时间对小鼠皮肤热损伤的实验与理论研究[J]. 强激光与粒子束, 2022, 34:011012 doi: 10.11884/HPLPB202234.210338 Zhou Xun, Ma Qiong, Liu Zhibo, et al. 1064 nm laser induced thermal injure in mice skin with different laser duration[J]. High Power Laser and Particle Beams, 2022, 34: 011012 doi: 10.11884/HPLPB202234.210338
[14]	Kagan R J, Peck M D, Ahrenholz D H, et al. Surgical management of the burn wound and use of skin substitutes: an expert panel white paper[J]. Journal of Burn Care & Research, 2013, 34(2): e60-e79.
[15]	Ganguly M, Mitra K. A modeling study to analyze thermal and mechanical effects of pulsed laser irradiation on tissues[J]. Computational Thermal Sciences: an International Journal, 2015, 7(5/6): 459-465.