The response surface model of Hypersonic Low Temperature(HYLTE) nozzle was built, and the design matrix of sample data points, used in this model, was derived by orthogonal design of experiment(DOE) procedure. The sample data were obtained by the nozzle and cavity flowfield calculation using computational fluid dynamics(CFD) method based on 3-dimensional viscous Navier-Stokes equation. Using the nozzle response surface model, multi-objective optimization of nozzle configuration was implemented. An integrated performance parameter was defined to evaluate the nozzle efficiently. Results indicate that the mixing of the optimized nozzle is enhanced remarkably and the integrated performance improves. So the optimization strategy based on response surface can satisfy the requirement for precisio