Based on published fracture experiments and 3D transient finite-element analyses, and taking the first principal stress as the criterion and the Griffith crack theory to determine the critical fracture stress, a Weibull statistical model is established to predict the fracture possibility of Nd:glass with certain pump parameters. Other issues which limit the pump power are also presented. The results show that the fracture limit of laser medium depends on the optical polishing technology. For a short pulse and high energy Nd:glass laser, taking Americas polishing technology in the 1990s as reference, the pump saturation limits the pump power to 18 kW/cm2 when the repetition rate is lower than 1 Hz, while the thermal fracture limits the pump power when the repetition rate is higher than 10 Hz.