Abstract: This paper utilizes MCNP method together with the MCAM software (Monte-Carlo Automatic Modeling) to simulate the shielding performance of the laser fusion experimental facilitys target chamber, in the meanwhile, provides theoretical foundation for the establishment of the shielding system, radiation protection of personnel as well as the selection of the target chamber from radiation protection perspective. The simulation results show that the instantaneous gamma dose in the non-channel area is reduced by 50% when CLAM steel (China Low Activity Martensitic Steel) was applied as the chamber material comparing to the aluminum alloy. In addition, the neutron and gamma dose are decreased one level by using the heavy concrete with a thickness of 40 cm (aluminum alloy as the chamber target). It is worth mentioning that the neutron and gamma dose in the channel area is 10% larger than the bared target, so extra protection should be considered outside the hole.