Abstract: The accuracy in reverberation chamber (RC) measurements depends on the chamber settings being able to generate a large number of independent measurement samples. In this paper, an approximate theoretical model of the number of independent samples is derived by theoretically analyzing how the RC configuration and the frequency influence the number of independent samples, and the model is improved and verified by comparing a large amount of experimental data and calculation. The results show that the number of independent samples positively correlates with chamber volume, quality factor, and stirrer size, and negatively correlates with the electrical size of stirrers in a certain range. The model can be used to calculate the number of independent samples in RCs of different configurations, with good accuracy and generality.